Thursday, April 4, 2013

N. Korea moves missile after warning U.S.

SEOUL, South Korea (AP) ? North Korea has moved a missile with "considerable range" to its east coast, South Korea's defense minister said Thursday, but he added that there are no signs that Pyongyang is preparing for a full-scale conflict.

The report came hours after North Korea's military warned that it has been authorized to attack the U.S. using "smaller, lighter and diversified" nuclear weapons. It was the North's latest war cry against America in recent weeks. The reference to smaller weapons could be a claim that Pyongyang has improved its nuclear technology. Or a bluff.

South Korean Defense Minister Kim Kwan-jin said he did not know the reasons behind the North's missile movement, and that it "could be for testing or drills."

He dismissed reports in Japanese media that the missile could be a KN-08, which is believed to be a long-range missile that if operable could hit the United States.

Kim told lawmakers at a parliamentary committee meeting that the missile has "considerable range" but not enough to hit the U.S. mainland.

The range he described could refer to a mobile North Korean missile known as the Musudan, which has a range of 3,000 kilometers (1,800 miles). That would make Japan and South Korea potential targets ? along with U.S. bases in both countries ? but there are doubts about the missile's accuracy.

The Pentagon announced that it will deploy a missile defense system to the U.S. Pacific territory of Guam to strengthen regional protection against a possible attack.

Experts say North Korea has not demonstrated that it has missiles capable of long range or accuracy. Some suspect that long-range missiles unveiled by Pyongyang at a parade last year were actually mockups.

"From what we know of its existing inventory, North Korea has short- and medium-range missiles that could complicate a situation on the Korean Peninsula (and perhaps reach Japan), but we have not seen any evidence that it has long-range missiles that could strike the continental U.S., Guam or Hawaii," James Hardy, Asia Pacific editor of IHS Jane's Defence Weekly, wrote in a recent analysis.

Kim Kwan-jin said that if North Korea were preparing for a full-scale conflict, there would be signs including the mobilization of a number of units, including supply and rear troops, but South Korean military officials have found no such preparations.

"(North Korea's recent threats) are rhetorical threats. I believe the odds of a full-scale provocation are small," he said. But he added that North Korea might mount a small-scale provocation such as its 2010 shelling of a South Korean island, an attack that killed four people.

Pyongyang has been railing against joint U.S. and South Korean military exercises taking place in South Korea and has expressed anger over tightened U.N. sanctions for its February nuclear test. Many of the threats come in the middle of the night in Asia ? daytime for the U.S. audience.

Analysts say the threats are probably efforts to provoke softer policies from South Korea, to win diplomatic talks with Washington and to solidify the image of young North Korean leader Kim Jong Un.

At times, Pyongyang has gone beyond rhetoric.

On Tuesday, it announced it would restart a plutonium reactor it had shut down in 2007. A U.S. research institute said Wednesday that satellite imagery shows that construction needed for the restart has already begun.

For a second day Thursday, North Korean border authorities denied entry to South Koreans who manage jointly run factories in the North Korean city of Kaesong. South Koreans already at the plant were being allowed to return home.

Defense Minister Kim said South Korea has prepared a military contingency plan should North Korea hold South Korean workers hostage in Kaesong, Kim said. He wouldn't elaborate.

Outraged over comments in the South about possible hostage-taking and a military response from Seoul, a North Korean government-run committee threatened to pull North Korean workers out of Kaesong as well.

North Korea's military statement Thursday, from an unnamed spokesman from the General Bureau of the Korean People's Army, said its troops had been authorized to counter U.S. "aggression" with "powerful practical military counteractions," including nuclear weapons.

It said America's "hostile policy" and "nuclear threat" against North Korea "will be smashed by the strong will of all the united service personnel and people and cutting-edge smaller, lighter and diversified nuclear strike means."

U.S. Defense Secretary Chuck Hagel said Washington is doing all it can to defuse the situation.

"Some of the actions they've taken over the last few weeks present a real and clear danger and threat" to the U.S. and its allies, Hagel said Wednesday.

South Korea's Defense Ministry said its military is ready to deal with any provocation by North Korea. "I can say we have no problem in crisis management," deputy ministry spokesman Wee Yong-sub told reporters.

The defense minister, however, was criticized by lawmakers over a North Korean defector who stole a South Korean fishing boat Wednesday night and fled back to North Korea across the western sea border.

Kim said South Korean radar has a "blind spot" in the area and South Korean troops were unaware the defector was fleeing until he almost reached the North Korean side. Lawmakers questioned his military's readiness to detect and counter enemy troops who might use similar blind spots.

This spring's annual U.S.-South Korea drills have incorporated fighter jets and nuclear-capable stealth bombers. The allies insist they are routine exercises. Pyongyang calls them rehearsals for a northward invasion and says it needs nuclear weapons to defend itself.

On Sunday, Kim Jong Un led a high-level meeting of party officials who declared building the economy and "nuclear armed forces" as the nation's priorities.

Pyongyang is believed to be working toward building an atomic bomb small enough to mount on a long-range missile. Long-range rocket launches designed to send satellites into space in 2009 and 2012 were widely considered covert tests of missile technology, and North Korea has conducted three underground nuclear tests.

"I don't believe North Korea has the capacity to attack the United States with nuclear weapons mounted on missiles, and won't for many years. Its ability to target and strike South Korea is also very limited," nuclear scientist Siegfried Hecker, a senior fellow at the Center for International Security and Cooperation at Stanford University, said this week.

In comments posted to CISAC's website, Hecker said North Korea knows a nuclear attack would be met with "a devastating nuclear response."

Hecker has estimated that North Korea has enough plutonium to make several crude nuclear bombs. Its announcement Tuesday that it would restart a plutonium reactor indicated that it intends to produce more nuclear weapons material.

The U.S.-Korea Institute at Johns Hopkins School of Advanced International Studies has analyzed recent commercial satellite imagery of the Nyongbyon nuclear facility, where the reactor was shut down in 2007 under the terms of a disarmament agreement. A cooling tower for the reactor was destroyed in 2008.

The analysis published Wednesday on the institute's website, 38 North, says that rebuilding the tower would take six months, but a March 27 photo shows building work may have started for an alternative cooling system that could take just weeks. Experts estimate it could take three months to a year to restart the plant.

___

Associated Press writers Matthew Pennington in Washington and Youkyung Lee in Seoul contributed to this report.

Source: http://news.yahoo.com/skorea-north-korea-moved-missile-east-coast-062418562.html

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Roku 3 review: our favorite media streamer, and the simplest to use, too

Roku 3 review: our favorite media streamer, and the simplest to use, too

Roku's media streamers have carved out a notable niche for themselves, with what started out as a Netflix box, but quickly grew to include hundreds of other entertainment options. Whatever they've lacked in style, they've always made up for with an easy-to-navigate menu and remote, not to mention low prices. In fact, they've become our default recommendation in the set-top box category, and now the company is back with its third iteration.

Its approach hasn't changed: the Roku 3 is still a simple $99 box that brings internet content including video, some simple apps and even games to your TV. But this one is touted as the most powerful Roku ever, and the team behind it has even dared to tweak that boring, but simple menu system. There have always been some rough edges that needed polishing, along with holes in its offerings -- join us to see if it's good enough to be the best.

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Source: http://www.engadget.com/2013/04/03/dnp-roku-3-review/

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In The Name Of Science, Head-Bobbing Sea Lion Keeps The Beat

While rhythm can often be hard enough to find among humans, finding it in the animal kingdom has been even more rare.

But thanks to a 3-year-old sea lion named Ronan who knows how to keep the beat, previous notions of rhythmic ability among animals are now being challenged.

The research team at the University of California at Santa Cruz's Pinniped Cognition and Sensory Systems Laboratory says Ronan is the first nonhuman mammal to show evidence of beat keeping, something previously seen mostly in parrots and cockatoos.

"The fact that we showed Ronan could do it means that there's a raw capability in sea lions," lead researcher Peter Cook, a graduate student in psychology at UC-Santa Cruz, told NBC News.

Previously, Cook says, beat-keeping ability was thought to be tied to vocal mimicry, which is why birds can do it. Sea lions, however, are not vocal mimics, so Ronan's ability to bob her head to the beat of "Boogie Wonderland" and The Backstreet Boys could mean that rhythmic ability in the animal kingdom might be more common.

We're not quite sure what this means for science, but it sure is cute.

Source: http://www.npr.org/blogs/thetwo-way/2013/04/02/176047593/in-the-name-of-science-head-bobbing-sea-lion-keeps-the-beat?ft=1&f=1007

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Monday, April 1, 2013

Becoming Human: Humankind's destructive streak may be older than the species itself

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Source: http://www.sciencenews.org/view/generic/id/349305/title/Humankinds_destructive_streak_may_be_older_than_the__species_itself

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Looking for a fitness buddy? Get a dog

By Dorene Internicola

NEW YORK (Reuters) - Zeus the pit bull helps his owner slog through interval training and military crawls, Goldie and her master enjoy Tai Chi together and Izzie the three-legged shih tzu can't hike up the mountain but she acts as a hand weight for her owner's bicep curl.

Experts say a dog may be man's best fitness friend, and dog-and-master workouts don't have to be limited to a run on the beach or a Frisbee toss.

"Unlike humans, their motivation never peters out. Dogs don't drop off one by one, like other fitness buddies," said Dr. Marty Becker, an Idaho-based veterinarian and author of "Fitness Unleashed: A Dog and Owner's Guide to Losing Weight and Gaining Health Together."

Becker cited statistics he said show that 56 percent of dogs and cats and 66 percent of people are overweight in America.

Bow Wow Bootcamp, Tai Chi Wa Wa and Pupilates, are a few of the group fitness class offered to humans and their dogs at K9 Fit Club, which has locations in Illinois, Tennessee, Pennsylvania and Florida.

Founder Tricia Montgomery was working for the Chicago Veterinary Medical Association when the idea of a gym for people and pets occurred to her.

Behind the cute names is a serious purpose.

"We are not just a bunch of people getting together with our dogs," said Montgomery. "Our programs are designed by certified trainers and psychologists."

Fitness professionals and animal trainers lead the 55-minute classes, she said, which are limited to eight to 10 people and their pets.

"Every one of the classes we do follows a complete (client) assessment that includes a behavior assessment for the companion animal," Montgomery explained.

For people without a dog, the gym will work with a shelter to provide one, she said.

"Some people I deal with are morbidly obese. They're intimidated by gyms," she said. "The dog's not going to judge you. And they'll never cancel on you."

San Diego, California-based fitness trainer Tamilee Webb incorporates her three-legged shi tzu Izzie in much of her daily regime.

"If I go for walk or hike, she?s in a doggy backpack to add a little extra weight," said Webb. "I'll do squats, lunges and pushes and she'll still be on my back."

Webb is the creator of the "Buns of Steel" and "Abs of Steel" DVD series. She has also taught a pooch boot camp.

"I would take a group of six to 10 mostly women and their dogs, big or small, on a walk," she said. "Then we'd stop and do exercises, sometimes with rubber tubing, sometimes with the small dogs as resistance."

At least 39 percent of American households include at least one dog, according to the Humane Society. A 2011 study from Michigan State University found that people who owned and walked their dogs were 34 percent more likely to meet the federal benchmarks on physical activity.

"I think a pet gets you out to be active," said Webb. "Working dogs need at least 30 minutes of exercise and two hours of activity," she said. "Little dogs don't need that much."

Webb has taken bigger breeds and their owners up and down stairs, on runs, and in pools.

"In San Diego, you can take a dog surfing," she said. "And there's Doga (yoga for dogs)."

Becker, who has four dogs, as well as some cats and horses, favors a back-to-basics approach to human-dog fitness.

"The great thing about exercising with a pet is that you don't need a gym and you don't need expensive equipment," he said. "All you need is a good pair of shoes and a walking leash and you're out the door."

For dogs, it's all about the cardio, he explained.

"There are no bikini seasons for dogs, no trying to get into last season's Levis," he said. "And dogs do their own stretches."

(Editing by Patricia Reaney)

Source: http://news.yahoo.com/looking-fitness-buddy-dog-171149913.html

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Mechanism of mutant histone protein in childhood brain cancer revealed

Apr. 1, 2013 ? Most cancer treatments are blunt. In an attempt to eradicate tumors, oncologists often turn to radiation or chemotherapy, which can damage healthy tissue along with the cancerous growths. New research from C. David Allis' laboratory at Rockefeller University may bring scientists closer to designing cancer therapeutics that can target tumors with pinpoint accuracy.

Their findings, published in Science Express, follow a recent series of discoveries by several international genome sequencing consortiums that directly links a mutated histone protein to a rare brain stem cancer in children called DIPG. Collectively, these studies represented the first time scientists had linked a histone mutation to a disease, and piqued the interest of Peter Lewis, a research associate in Allis' Laboratory of Chromatin Biology and Epigenetics, who spearheaded these new studies.

Together with DNA, histones comprise the gene packaging material called chromatin. The mutation occurs on histone H3, and involves the remarkably specific substitution of one amino acid, lysine, for another, methionine, at a key position on the histone's tail, "silencing" the associated gene. Normally, gene silencing arises when an enzyme called a methyltransferase, containing a structural region called the SET domain, attaches a methyl chemical group to the lysine at position 27 in the H3 tail. This highly specific chemical reaction, called methylation, is disrupted by the replacement of the lysine with methionine, which could result in gene mis-regulation.

Lewis and his colleagues looked at human DIPG tumors that contained the lysine-to-methionine substitution and determined that mutated histone H3 comprised anywhere from 3.6 percent to 17.6 percent of total H3 in DIPG samples. They also found a global reduction in the levels of methylation of normal H3 histones when small amounts of the mutant H3 were added to normal human cells.

"I have often said, 'Every amino acid in histones matters,'" says Allis, who is the Joy and Jack Fishman Professor. "These studies underscore just how true that may be."

The researchers went on to demonstrate that the reduction in methylation of normal H3 histones results from interference with activity of a methyltransferase called PRC2 by the mutant histone. Methylation of normal H3 by PRC2 leads to repression of genes involved in cellular growth pathways. Without methylation, genes involved in these pathways likely become activated, promoting the growth of tumors in DIPG. Allis and Lewis received funding from the National Institutes of Health and the Starr Cancer Consortium. Key collaborators in this work included Oren Becher at Duke University Medical Center and Tom Muir at Princeton University and their colleagues.

"Our finding provides us with a useful tool for probing biological processes," says Lewis. "This also tells us how to inhibit enzymes, which could lead to the development of pharmaceuticals that mimic the action of these mutants."

"We now have a model for the promotion of brain stem cancers through aberrant epigenetic silencing through the inhibition of PRC2 by a mutant histone," says Allis. "We have uncovered a potentially useful mechanism to exclusively inhibit individual SET-domain methyltransferases, and conceivably other chromatin-modifying enzymes, implicated in a variety of malignancies."

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The above story is reprinted from materials provided by Rockefeller University.

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Journal Reference:

  1. P. W. Lewis, M. M. Muller, M. S. Koletsky, F. Cordero, S. Lin, L. A. Banaszynski, B. A. Garcia, T. W. Muir, O. J. Becher, C. D. Allis. Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma. Science, 2013; DOI: 10.1126/science.1232245

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/40YXt_m5Bp8/130401132054.htm

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Celebrities Who Won Google Glass - Business Insider

Astrid Stawiarz/Getty Images

Google's #ifihadglass competition spurred a number of applications from everyday people, as well as from some high-profile celebrities.

Google is still announcing the winners of its #ifihadglass contest, but there's already handful of celebrities who have been selected.

Andrej Karpathy, a PhD student at Stanford,?created a database of the winners of Glass, sorted by the number of followers they have.?As of right now, there are only 2,318 people on the list, so there might be more celebrities out there with invitations to try Glass. Also, the list only takes into account people who won via Twitter, not via Google+.

Even though these celebrities won the contest, it doesn't necessarily mean they'll fork over the $1,500 to get a pair. But we bet it wouldn't do too much damage to their wallets.?

Source: http://www.businessinsider.com/celebrities-who-won-google-glass-2013-3

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